PATIENT BIOLOGIC EDUCATION
THE DISEASE
RA (AS, PsA) is an autoimmune disease.
Your body’s immune system protects you from infection by attacking bacteria and viruses that invade your body. In autoimmune disease your immune system stays stimulated. Over production of TNF by some immune cells results in an exaggerated immune and inflammatory response and is one of the main culprits that lead to joint and bone damage.
BIOLOGICS
Biologics are disease modifying agents. It is a protein that resembles a human antibody which targets TNF, thereby blocking the effect in its continual inflammatory cycle.
Simply put – Biologics switches off your disease and allows your body to heal itself.
Benefits are maintained as long as you stay on Biologics.
TB
Your doctor has checked you for TB. This is important as TNF is one of the proteins in your immune system that prevents the TB bacteria from spreading in your body. As this is the same protein that contributes to the symptoms of your disease, by blocking its action, it does leave you more susceptible to TB.
It is important that you be checked annually.
Tell your doctor as soon as possible if you develop any symptoms or signs of TB.
• Mild fever
• Persistent cough
• Weight loss
• Listlessness
• Swollen glands
If you think you have been exposed, contact your doctor.
SAFETY INFORMATION
Biologics can increase your risk of infection. You need to be aware of this so that if you develop any signs and symptoms of infection, you can contact your GP or Rheumatologist urgently and receive prompt treatment. These include:
• Fever
• Wounds
• Coughing
• General unwell feeling
• Dental problems
• Burning on urination
• Feeling weak and tired
Tell your doctor if you develop signs and symptoms of nervous system disorders:
• Numbness or tingling
• Arm or leg weakness
• Double vision
Tell your doctor if you experience an allergic reaction. Signs and symptoms include:
• Severe rash
• Swollen face, hands or feet
• Hives
• Trouble breathing or swallowing
• The needle cover contains natural rubber (latex). Patients sensitive to latex should avoid touching the inner shield
Seek medical attention immediately if you develop symptoms of heart failure, including:
• Shortness of breath with exertion or lying down
• Swollen feet
If you are about to undergo surgery or dental procedures please inform your doctor that you are taking a Biologic. Speak to your Surgeon and Rheumatologist – who will decide whether you should stop Orencia before your operation, and when to restart after the operation.
People with more serious Rheumatoid Arthritis may have a higher than average risk of getting Lymphoma. If you take biologics, your risk may increase.
Possible Other Side Effects of ORENCIA® (abatacept)
(www.orencia.com, accessed 7/7/2014)
ORENCIA can cause serious side effects including:
•Hepatitis B infection. If you are a carrier of the hepatitis B virus (a virus that affects the liver), the virus can become active while you use ORENCIA. Your healthcare provider may do a blood test before you start or while using ORENCIA.
•Vaccinations. You should not receive ORENCIA with certain types of vaccines. ORENCIA may cause some vaccinations to be less effective.
•Respiratory problems in patients with COPD. You may get certain respiratory problems more often if you receive ORENCIA and have COPD, including: worsened COPD, pneumonia, cough, or trouble breathing.
•Common side effects with ORENCIA are headache, upper respiratory tract infection, sore throat, and nausea.
Tell your doctor if you are taking any over the counter medication. Products that contain Echinacea or products that boost the immune system should be avoided as they stimulate TNF production.
Travelling with Biologics
Check with your Doctor.
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